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- 23/12/29 黄志伟获得了2023年科技部重点研发计划“揭榜挂帅”项目（2023YFF1000200）
- 23/01/13 黄志伟教授入选首批新基石研究员
- 22/12/17 黄志伟获得了2022年药明康德生命化学研究奖管理委员会颁发的“药明康德生命化学研究奖”
- 22/08/19 黄志伟课题组在《科学》（Science）发文揭示人B细胞受体复合物组装的分子机制
- 22/03/10 生命学院黄志伟教授课题组揭示胆固醇抑制T细胞受体活性的分子机制
学术交流
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第四十五期“青年学者论坛”—许琛琦博士报告会
2019年6月28日下午，中国科学院生化与细胞所许琛琦博士做客我校第四十五期“青年学者论坛”，并为我校师生带来题为“Signaling and metabolic checkpoints in T cells”的报告。
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清华大学王新泉教授学术报告会
应我校科工院邀请，清华大学生命科学学院副院长、清华大学结构生物学高精尖创新中心副主任—王新泉教授于4月18日下午来我校访问并带来精彩学术报告，会议由生命学院院长黄志伟教授主持。
RESEARCH
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宿主免疫防御与微生物感染的分子机制
Dissecting the molecular mechanisms involved in host immune defenses and microbial infection
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人适应性免疫系统的分子机制
Dissecting the molecular mechanisms involved in human adaptive immune system.
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人体微生态系统及相关疾病的机制
Investigating the underlying mechanisms of microbial dysbiosis in human diseases.
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研发新型CRISPR-Cas基因编辑工具进行遗传病等的治疗应用
Developing novel CRISPR-Cas genome editing tools for the treatment of genetic disorders.
our team
Yuwei Zhu, Ph.D.
Associate Professor
Minghui Guo
Assistant Professor
De Dong
Assistant Professor
Yan Chen, Ph.D.
Postdoctoral Fellow
Dehui Yang
Lab Manager
Zhenlei Yue
Lab Manager
Jianlin Zheng
Graduate Student
Fengxia Zhou
Graduate Student
Kuan Ren
Graduate Student
Shuo Wang
Graduate Student
Ling Yu
Graduate Student
Ziqi Zhen
Graduate Student
Xiang Li
Graduate Student
Chuangeng Chen
Graduate Student
Xiaorong Yu
Graduate Student
Ye Bai
Graduate Student
Xinyu Ma
Graduate Student
Shubo Wang
Graduate Student
Zebin Lu
Graduate Student
Shouyu Wang
Postgraduate Student
Meng Cui
Postgraduate Student
Mingyu Yin
Undergraduate
Xinyu Tian
Undergraduate
Zhiying Lin
Undergraduate
Buliao Huang
Undergraduate
Wenbo Gao
Undergraduate
Bailing Zhang
Lab Manager
Shuangyu Xie
Technician
Mingyue He
Technician
Liyong Dong
Graduate Student
Hongnan Liu
Graduate Student
Yuhang Wang
Graduate Student
Shijie Sun
Postgraduate Student
Rui Gan
Postgraduate Student
Jianquan Lin
Postgraduate Student
Minjia Zhou
Postgraduate Student
Yu Si
Postgraduate Student
Han Yang
Postgraduate Student
Ye Tian
Postgraduate Student
PUBLICATIONS
- Minghui Guo*, Yuwei Zhu*, Zhiying Lin*, Dehui Yang, Anqi Zhang, Changyou Guo and Zhiwei Huang#.Cryo-EM structure of the ssDNA-activated SPARTA complex. Cell Research. 33(9)(2023):731-734.
- Fengxia Zhou*#, Xiaorong Yu*, Rui Gan*, Kuan Ren*, Chuangeng Chen, Chunyan Ren, Meng Cui, Yuchen Liu, Yiyang Gao, Shouyu Wang, Mingyu Yin, Tengjin Huang, Zhiwei Huang# and Fan Zhang#. CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing. Nucleic Acids Research. 51(W1)(2023):W93-W107.
- Shuo Wang*, Minghui Guo*, Yuwei Zhu*, Zhiying Lin and Zhiwei Huang#. Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT. Cell Research. 32(12)(2022):1128-1131.
- Xinyu Ma*, Yuwei Zhu*, De Dong*, Yan Chen*, Shubo Wang, Dehui Yang, Zhuo Ma, Anqi Zhang, Fan Zhang, Changyou Guo and Zhiwei Huang#. Cryo-EM structures of two human B cell receptor isotypes. Science. 377(6608)(2022):880-885.
- Yan Chen*, Yuwei Zhu*, Xiang Li*, Wenbo Gao*, Ziqi Zhen, De Dong, Buliao Huang, Zhuo Ma, Anqi Zhang, Xiaocui Song, Yan Ma, Changyou Guo, Fan Zhang, Zhiwei Huang#(2022). Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility, Molecular Cell, S1097-2765(22)00155-1
- Fengxia Zhou*, Rui Gan*, Fan Zhang*, Chunyan Ren, Ling Yu, Yu Si, Zhiwei Huang# (2022). PHISDetector: A tool to detect diverse in silico phage–host interaction signals for virome studies, Genomics, Proteomics & Bioinformatics, S1672-0229(22)00017-1.
- Shengli Ma*#, Fan Zhang*, Fengxia Zhou*, Hui Li*, Wenyu Ge, Rui Gan, Huan Nie, Biao Li, Yindong Wang, Meng Wu, Duo Li, Dongmei Wang, Zheng Wang, and Yuhong You, Zhiwei Huang# (2021). Metagenomic analysis reveals throat microbiota alterations in patients with COVID-19. Signal Transduction Targeted Therapy. 6, 191.
- Xianwen Ren*, Wen Wen*, Xiaoying Fan*, Wenhong Hou*, Bin Su*, Pengfei Cai*, Jiesheng Li*, Yang Liu*, Fei Tang*, Fan Zhang*, Yu Yang*……Zhiwei Huang#, Jin-Xin Bei#, Lai Wei#, Xiu-Wu Bian#, Xindong Liu#, Tao Cheng#, Xiangpan Li#, Pingsen Zhao#, Fu-Sheng Wang#, Hongyang Wang#, Bing Su#, Zheng Zhang#, Kun Qu#, Xiaoqun Wang#, Jiekai Chen#, Ronghua Jin#, Zemin Zhang# (2021). COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 184(7):1895-1913.
- Hongnan Liu*, Yuwei Zhu*, Zebin Lu, Zhiwei Huang# (2021). Structural basis of Staphylococcus aureus Cas9 inhibition by AcrIIA14. Nucleic Acids Res. 21;49(11):6587-6595.
- Zhang, F.*, R. Gan*, Z. Zhen*, X. Hu*, X. Li, F. Zhou, Y. Liu, C. Chen, S. Xie, B. Zhang, X. Wu and Z. Huang# (2020). "Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals." Signal Transduct Target Ther 5(1): 156.
- Kaiming Zhang*, Shuo Wang*, Shanshan Li*, Yuwei Zhu*, Grigore D Pintilie , Tung-Chung Mou , Michael F Schmid , Zhiwei Huang#, Wah Chiu（2020）. Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM . Proc Natl Acad Sci U S A. 117(13):7176-7182.
- Liyong Dong*, Xiaoyu Guan*, Ningning Li*, Fan Zhang, Yuwei Zhu, Kuan Ren, Ling Yu, Fengxia Zhou, Zhifu Han, Ning Gao & Zhiwei Huang# (2019). An anti-CRISPR protein disables type V Cas12a by acetylation. Nature Structural & Molecular Biology. 26(4):308-314.
- Minghui Guo*, Kaiming Zhang*, Yuwei Zhu, Grigore D. Pintilie, Xiaoyu Guan, Shanshan Li, Michael F. Schmid, Zhuo Ma, Wah Chiu# & Zhiwei Huang# (2019). Coupling of ssRNA Cleavage with DNase Activity in Type III-A CRISPR-Csm Revealed by Cryo-EM and Biochemistry. Cell Research. 29(4):305-312.
- Minghui Guo*, Kuan Ren*, Yuwei Zhu*, Ziyun Tang, Yuhang Wang, Bailing Zhang & Zhiwei Huang# (2019). Structural insights into a high fidelity variant of SpCas9. Cell Research. 29,183-192.
- De Dong*, Lvqin Zheng*, Jianquan Lin*, Bailing Zhang, Yuwei Zhu, Ningning Li, Shuangyu Xie, Yuhang Wang, Ning Gao# & Zhiwei Huang#(2019). Structural basis of assembly of the human TCR–CD3 complex. Nature. 2019 Aug 28. doi: 10.1038/s41586-019-1537-0.
- Yuwei Zhu, Zhiwei Huang# (2018). Recent advances in structural studies of the CRISPR-Cas-mediated genome editing tools. National Science Review. doi: 10.1093/nsr/nwy150
- Liuke Sun, Ruifang Shen, Sandeep K. Agnihotri, Yun Chen, Zhiwei Huang & Hansruedi Büeler# (2018). Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death. Scientific Reports. 8(1):383.
- Fan Zhang#, Shijia Zhao, Chunyan Ren, Yuwei Zhu, Haibin Zhou, Yongkui Lai, Fengxia Zhou, Yuqiang Jia, Kangjie Zheng & Zhiwei Huang# (2018). CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions. Communications Biology. 31;1:180.
- Yuwei Zhu, Fan Zhang, and Zhiwei Huang. Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins.
- De Dong*, Minghui Guo*, Sihan Wang*, Yuwei Zhu, Shuo Wang,Zhi Xiong, Jianzheng Yang, Zengliang Xu and Zhiwei Huang# (2017). Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. Nature. 546(7658):436-439.
- Dan Wu*, Xiaoyu Guan*, Yuwei Zhu*, Kuan Ren, Zhiwei Huang# (2017). Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA.Cell Research. 27(5):705-708.
- Marchisio# & Zhiwei Huang# (2017). CRISPR-Castype II-based Synthetic Biology applications in eukaryotic cells. RNA Biology. 14(10):1286-1293.
- Pu Gao, Hui Yang, Kanagalaghatta R Rajashankar, Zhiwei Huang and Dinshaw J Patel (2016). Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Research. 26(8):901-13.
- De Dong*, Kuan Ren*, Xiaolin Qiu*, Jianlin Zheng, Minghui Guo, Xiaoyu Guan, Hongnan Liu, Ningning Li, Bailing Zhang, Daijun Yang, Chuang Ma, Shuo Wang, Dan Wu, Yunfeng Ma, Shilong Fan, Jiawei Wang, Ning Gao and Zhiwei Huang# (2016). Crystal structure of CRISPR-Cpf1 in complex with CRISPR RNA (crRNA). Nature. 532(7600):522-6.
- Jae-Hyuck Shim, Matthew B. Greenblatt, Weiguo Zou, Zhiwei Huang, Marc N. Wein, Nicholas Brady, Dorothy Hu, Jean Charron, Heather R. Brodkin, Gregory A. Petsko, Dennis Zaller, Bo Zhai, Steven Gygi, Laurie H. Glimcher and Dallas C. Jones (2013). Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123(9):4010-22.
- Zehan Hu, Chuangye Yan, Peiyuan Liu, Zhiwei Huang, Rui Ma, Chenlu Zhang, Ruiyong Wang, Yueteng Zhang, Fabio Martinon, Di Miao, Haiteng Deng, Jiawei Wang, Junbiao Chang, Jijie Chai (2013). Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 341(6142):172-5.
- Chen D, Lei L, Flores R, Zhiwei Huang, Wu Z, Chai J, Zhong G. (2010). Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells. Microbial Pathogenesis. 49(4):164-73.
- Zhiwei Huang and Jijie Chai (2010). Mapping the selection mechanisms by bacterial GEFs. Virulence. 1(2):93-6.
- Zhiwei Huang, Yingcai Feng, Ding Chen, Xiaojing Wu, Xiaojun Wang, Xingguo Xiao, Wenhui Li, Niu Huang, Lichuan Gu, Guangming Zhong and Jijie Chai (2008). Structural basis for activation and inhibition of the secreted chlamydia protease CPAF. Cell Host & Microbe. 4(6):529-42. (This publication was selected as a research “highlight” by Nature China
- Maikke B. Ohlson, Zhiwei Huang, Neal M. Alto, Jack E. Dixon, Jijie Chai and Samuel I. Miller (2008). Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation. Cell Host & Microbe. 4(5):434-46.