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- Jianlin Zheng*,Yuwei Zhu*,Tengjin Huang,Wenbo Gao,Jiale He,Zhiwei Huang#. Inhibition mechanisms of CRISPR-Cas9 by AcrIIA25.1 and AcrIIA32. Science China Life Sciences, (2024): 1-11.
- Kuan Ren*, Fengxia Zhou*, Fan Zhang*, Mingyu Yin*, Yuwei Zhu*, Shouyu Wang*, Yan Chen, Tengjin Huang, Zixuan Wu, Jiale He, Anqi Zhang, Changyou Guo, Zhiwei Huang#. Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs. Cell Research, 34(5)(2024):370-385.
- Fengxia Zhou*#, Xiaorong Yu*, Rui Gan*, Kuan Ren*, Chuangeng Chen, Chunyan Ren, Meng Cui, Yuchen Liu, Yiyang Gao, Shouyu Wang, Mingyu Yin, Tengjin Huang, Zhiwei Huang# and Fan Zhang#. CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing. Nucleic Acids Research. 51(W1)(2023):W93-W107.
- Minghui Guo*, Yuwei Zhu*, Zhiying Lin*, Dehui Yang, Anqi Zhang, Changyou Guo and Zhiwei Huang#.Cryo-EM structure of the ssDNA-activated SPARTA complex. Cell Research. 33(9)(2023):731-734.
- Shuo Wang*, Minghui Guo*, Yuwei Zhu*, Zhiying Lin and Zhiwei Huang#. Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT. Cell Research. 32(12)(2022):1128-1131.
- Xinyu Ma*, Yuwei Zhu*, De Dong*, Yan Chen*, Shubo Wang, Dehui Yang, Zhuo Ma, Anqi Zhang, Fan Zhang, Changyou Guo and Zhiwei Huang#. Cryo-EM structures of two human B cell receptor isotypes. Science. 377(6608)(2022):880-885.
- Fengxia Zhou*, Rui Gan*, Fan Zhang*, Chunyan Ren, Ling Yu, Yu Si, Zhiwei Huang# (2022). PHISDetector: A tool to detect diverse in silico phage–host interaction signals for virome studies, Genomics, Proteomics & Bioinformatics, S1672-0229(22)00017-1.
- Yan Chen*, Yuwei Zhu*, Xiang Li*, Wenbo Gao*, Ziqi Zhen, De Dong, Buliao Huang, Zhuo Ma, Anqi Zhang, Xiaocui Song, Yan Ma, Changyou Guo, Fan Zhang, Zhiwei Huang#(2022). Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility, Molecular Cell, S1097-2765(22)00155-1
- Hongnan Liu*, Yuwei Zhu*, Zebin Lu, Zhiwei Huang# (2021). Structural basis of Staphylococcus aureus Cas9 inhibition by AcrIIA14. Nucleic Acids Res. 21;49(11):6587-6595.
- Xianwen Ren*, Wen Wen*, Xiaoying Fan*, Wenhong Hou*, Bin Su*, Pengfei Cai*, Jiesheng Li*, Yang Liu*, Fei Tang*, Fan Zhang*, Yu Yang*……Zhiwei Huang#, Jin-Xin Bei#, Lai Wei#, Xiu-Wu Bian#, Xindong Liu#, Tao Cheng#, Xiangpan Li#, Pingsen Zhao#, Fu-Sheng Wang#, Hongyang Wang#, Bing Su#, Zheng Zhang#, Kun Qu#, Xiaoqun Wang#, Jiekai Chen#, Ronghua Jin#, Zemin Zhang# (2021). COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 184(7):1895-1913.
- Shengli Ma*#, Fan Zhang*, Fengxia Zhou*, Hui Li*, Wenyu Ge, Rui Gan, Huan Nie, Biao Li, Yindong Wang, Meng Wu, Duo Li, Dongmei Wang, Zheng Wang, and Yuhong You, Zhiwei Huang# (2021). Metagenomic analysis reveals throat microbiota alterations in patients with COVID-19. Signal Transduction Targeted Therapy. 6, 191.
- Kaiming Zhang*, Shuo Wang*, Shanshan Li*, Yuwei Zhu*, Grigore D Pintilie , Tung-Chung Mou , Michael F Schmid , Zhiwei Huang#, Wah Chiu(2020). Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM . Proc Natl Acad Sci U S A. 117(13):7176-7182.
- Zhang, F.*, R. Gan*, Z. Zhen*, X. Hu*, X. Li, F. Zhou, Y. Liu, C. Chen, S. Xie, B. Zhang, X. Wu and Z. Huang# (2020). "Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals." Signal Transduct Target Ther 5(1): 156.
- De Dong*, Lvqin Zheng*, Jianquan Lin*, Bailing Zhang, Yuwei Zhu, Ningning Li, Shuangyu Xie, Yuhang Wang, Ning Gao# & Zhiwei Huang#(2019). Structural basis of assembly of the human TCR–CD3 complex. Nature. 2019 Aug 28. doi: 10.1038/s41586-019-1537-0.
- Minghui Guo*, Kuan Ren*, Yuwei Zhu*, Ziyun Tang, Yuhang Wang, Bailing Zhang & Zhiwei Huang# (2019). Structural insights into a high fidelity variant of SpCas9. Cell Research. 29,183-192.
- Minghui Guo*, Kaiming Zhang*, Yuwei Zhu, Grigore D. Pintilie, Xiaoyu Guan, Shanshan Li, Michael F. Schmid, Zhuo Ma, Wah Chiu# & Zhiwei Huang# (2019). Coupling of ssRNA Cleavage with DNase Activity in Type III-A CRISPR-Csm Revealed by Cryo-EM and Biochemistry. Cell Research. 29(4):305-312.
- Liyong Dong*, Xiaoyu Guan*, Ningning Li*, Fan Zhang, Yuwei Zhu, Kuan Ren, Ling Yu, Fengxia Zhou, Zhifu Han, Ning Gao & Zhiwei Huang# (2019). An anti-CRISPR protein disables type V Cas12a by acetylation. Nature Structural & Molecular Biology. 26(4):308-314.
- Yuwei Zhu, Fan Zhang, and Zhiwei Huang. Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins.
- Fan Zhang#, Shijia Zhao, Chunyan Ren, Yuwei Zhu, Haibin Zhou, Yongkui Lai, Fengxia Zhou, Yuqiang Jia, Kangjie Zheng & Zhiwei Huang# (2018). CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions. Communications Biology. 31;1:180.
- Liuke Sun, Ruifang Shen, Sandeep K. Agnihotri, Yun Chen, Zhiwei Huang & Hansruedi Büeler# (2018). Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death. Scientific Reports. 8(1):383.
- Yuwei Zhu, Zhiwei Huang# (2018). Recent advances in structural studies of the CRISPR-Cas-mediated genome editing tools. National Science Review. doi: 10.1093/nsr/nwy150
- Marchisio# & Zhiwei Huang# (2017). CRISPR-Castype II-based Synthetic Biology applications in eukaryotic cells. RNA Biology. 14(10):1286-1293.
- Dan Wu*, Xiaoyu Guan*, Yuwei Zhu*, Kuan Ren, Zhiwei Huang# (2017). Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA.Cell Research. 27(5):705-708.
- De Dong*, Minghui Guo*, Sihan Wang*, Yuwei Zhu, Shuo Wang,Zhi Xiong, Jianzheng Yang, Zengliang Xu and Zhiwei Huang# (2017). Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. Nature. 546(7658):436-439.
- De Dong*, Kuan Ren*, Xiaolin Qiu*, Jianlin Zheng, Minghui Guo, Xiaoyu Guan, Hongnan Liu, Ningning Li, Bailing Zhang, Daijun Yang, Chuang Ma, Shuo Wang, Dan Wu, Yunfeng Ma, Shilong Fan, Jiawei Wang, Ning Gao and Zhiwei Huang# (2016). Crystal structure of CRISPR-Cpf1 in complex with CRISPR RNA (crRNA). Nature. 532(7600):522-6.
- Pu Gao, Hui Yang, Kanagalaghatta R Rajashankar, Zhiwei Huang and Dinshaw J Patel (2016). Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Research. 26(8):901-13.
- Zehan Hu, Chuangye Yan, Peiyuan Liu, Zhiwei Huang, Rui Ma, Chenlu Zhang, Ruiyong Wang, Yueteng Zhang, Fabio Martinon, Di Miao, Haiteng Deng, Jiawei Wang, Junbiao Chang, Jijie Chai (2013). Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 341(6142):172-5.
- Jae-Hyuck Shim, Matthew B. Greenblatt, Weiguo Zou, Zhiwei Huang, Marc N. Wein, Nicholas Brady, Dorothy Hu, Jean Charron, Heather R. Brodkin, Gregory A. Petsko, Dennis Zaller, Bo Zhai, Steven Gygi, Laurie H. Glimcher and Dallas C. Jones (2013). Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123(9):4010-22.
- Zhiwei Huang and Jijie Chai (2010). Mapping the selection mechanisms by bacterial GEFs. Virulence. 1(2):93-6.
- Chen D, Lei L, Flores R, Zhiwei Huang, Wu Z, Chai J, Zhong G. (2010). Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells. Microbial Pathogenesis. 49(4):164-73.
- Maikke B. Ohlson, Zhiwei Huang, Neal M. Alto, Jack E. Dixon, Jijie Chai and Samuel I. Miller (2008). Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation. Cell Host & Microbe. 4(5):434-46.
- Zhiwei Huang, Yingcai Feng, Ding Chen, Xiaojing Wu, Xiaojun Wang, Xingguo Xiao, Wenhui Li, Niu Huang, Lichuan Gu, Guangming Zhong and Jijie Chai (2008). Structural basis for activation and inhibition of the secreted chlamydia protease CPAF. Cell Host & Microbe. 4(6):529-42. (This publication was selected as a research “highlight” by Nature China